Haematuria in association with Lynch syndrome

Hereditary Nonpolyposis Colorectal Cancer (HNPCC)/Lynch Syndrome: Surveillance and Diagnostic strategies

Introduction: Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) is an autosomal dominant genetic disease. The disease is caused by a mutation in one of four genes of the DNA mismatch repair system and increases the risk for various cancers, especially the uterine and colon cancers. The prevalence of this disease in the general population is about 1 in 500 and it causes about 2-3...

سندرم Lynch -l و گزارش شش مورد بیمار مبتلا

More than two decades ago, Henry T. Lynch reported a hereditary non polyposis colorectal cancer (HNPCC) which is seen in some families with dominant mode of inheritance, also know as Lynch Syndrome type I and II. This form to hereditary colorectal cancer has an early age of onset (Less than 45 years) with predominantly proximal colonic involvement (type I) and can also be associated with extrac...

Nutcracker phenomenon or nutcracker syndrome?

Sir, Chang et al. [1] describe a young patient in whom a nutcracker syndrome was diagnosed by magnetic resonance imaging and magnetic resonance angiography. Patients with nutcracker phenomenon are usually young and slim, and the diagnosis can be made by ultrasound. There are established criteria for the diagnosis of the entrapment of the left renal vein by two-dimensional ultrasonography and Do...

Genome wide association identified colorectal cancer susceptibility loci and colorectal cancer risk in Lynch syndrome

Background Recent genome-wide association studies (GWAS) have identified several common low-risk variants for colorectal cancer. Although some of the GWAS were enriched for young onset and family history positive colorectal cancer cases, it is not clear if these variants modify colorectal cancer risk for people with Lynch syndrome. In a case-unaffected sibling analysis of population and clinic ...

Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model.